Curcuma longa L.

Tue, 20 Jan 2009 21:37:40 +0100


  • Aggarwal B, Kumar A, Aggarwal M, Shishodia S. Curcumin derived from turmeric (Curcuma longa) : a spice for all seasons. In: Bagchi D, Preuss H, eds. Phytopharmaceuticals in Cancer Chemoprevention. Boca Raton, Fla: CRC Press; 2005:349-387.
  • Aggarwal BB, Takada Y, Oommen OV. From chemoprevention to chemotherapy: common targets and common goals. Expert Opin Invest Drugs 2004;13:1327-1338.
  • Anuchapreeda S, Leechanachai P, Smith MM et al. Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells. Biochem Pharmacol 2002;64:573-582.
  • Arafa HM. Curcumin attenuates diet-induced hypercholesterolemia in rats. Med Sci Monit 2005;11:BR228-BR234.
  • Azuine MA, Bhide SV. Chemopreventive effect of turmeric against stomach and skin tumors induced by chemical carcinogens in Swiss mice. Nutr Cancer 1992;17:77-83.
  • Bava SV, Puliappadamba VT, Deepti A et al. Sensitization of Taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerization. J Biol Chem 2005;280:6301-6308.
  • Bensky D, Clavey S, Stogër E, Gamble A. Yu Jin. Chinese Herbal Medicine: Materia Medica. 3rd ed. Seattle: Eastland Press; 2004:609-612.
  • Blumenthal M, Busse W, Goldberg A et al. The Complete German Commission E Monographs. Austin, Texas: American Botanical Council: Integrative Medicine Communications; 1998.
  • Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa) . J Altern Complement Med 2003;9:161-168.
  • Chearwae W, Anuchapreeda S, Nandigama K et al. Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from turmeric powder. Biochem Pharmacol 2004;68:2043-2052.
  • Chen J, Chen T. Chinese Medical Herbology and Pharmacology. City of Industry, Calif: Art of Medicine Press Inc; 2004.
  • Cheng AL, Hsu CH, Lin JK et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 2001;21:2895-2900.
  • Chuang SE, Yeh PY, Lu YS et al. Basal levels and patterns of anticancer drug-induced activation of nuclear factor-kappaB (NF-κB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells. Biochem Pharmacol 2002;63:1709-1716.
  • Chueh SC, Lai MK, Liu IS et al. Curcumin enhances the immunosuppressive activity of cyclosporine in rat cardiac allografts and in mixed lymphocyte reactions. Transplant Proc 2003;35:1603-1605.
  • Deters M, Klabunde T, Meyer H et al. Effects of curcumin on cyclosporine-induced cholestasis and hypercholesterolemia and on cyclosporine metabolism in the rat. Planta Med 2003;69:337-343.
  • ESCOP. Curcumae longae rhizoma. ESCOP Monographs: the Scientific Foundation for Herbal Medicinal Products. 2nd ed. Exeter, UK: European Scientific Cooperative on Phytotherapy and Thieme; 2003:107-117.
  • Frawley D, Lad V. The Yoga of Herbs . Twin Lakes, Wis: Lotus Press; 1986.
  • Garcea G, Berry DP, Jones DJ et al. Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. Cancer Epidemiol Biomarkers Prev 2005;14:120-125.
  • Gukovsky I, Reyes CN, Vaquero EC et al. Curcumin ameliorates ethanol and nonethanol experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol 2003;284:G85-G95.
  • Harbottle A, Daly AK, Atherton K, Campbell FC. Role of glutathione S-transferase P1, P-glycoprotein and multidrug resistance–associated protein 1 in acquired doxorubicin resistance. Int J Cancer 2001;92:777-783.
  • Hemaiswarya S, Doble M. Potential synergism of natural products in the treatment of cancer. Phytother Res 2006;20:239-249.
  • Iqbal M, Sharma SD, Okazaki Y et al. Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Pharmacol Toxicol 2003;92:33-38.
  • Jones EA, Shoskes DA. The effect of mycophenolate mofetil and polyphenolic bioflavonoids on renal ischemia reperfusion injury and repair. J Urol 2000;163:999-1004.
  • Kang G, Kong PJ, Yuh YJ et al. Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression by inhibiting activator protein 1 and nuclear factor kappa B bindings in BV2 microglial cells. J Pharmacol Sci 2004;94:325-328.
  • Karunagaran D, Rashmi R, Kumar TR. Induction of apoptosis by curcumin and its implications for cancer therapy. Curr Cancer Drug Targets 2005;5:117–29;
  • Khafif A, Hurst R, Kyker K et al. Curcumin: a new radio-sensitizer of squamous cell carcinoma cells. Otolaryngol Head Neck Surg 2005;132:317-321.
  • Khopde SM, Priyadarsini KI, Guha SN et al. Inhibition of radiation-induced lipid peroxidation by tetrahydrocurcumin: possible mechanisms by pulse radiolysis. Biosci Biotechnol Biochem 2000;64:503-509.
  • Kositchaiwat C, Kositchaiwat S, Havanondha J. Curcuma longa Linn. in the treatment of gastric ulcer comparison to liquid antacid: a controlled clinical trial. J Med Assoc Thai 1993;76:601-605.
  • Kuroda M, Mimaki Y, Nishiyama T et al. Hypoglycemic effects of turmeric ( Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice. Biol Pharm Bull 2005;28:937-939.
  • Menon LG, Kuttan R, Kuttan G. Anti-metastatic activity of curcumin and catechin. Cancer Lett 1999;141:159-165.
  • Mills S, Bone K. The Essential Guide to Herbal Safety. St Louis: Churchill Livingstone; 2005.
  • Mitchell TM. Correspondence re: Somasundaram et al., Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res 62:3868-3875, 2002. Cancer Res 2003;63:5165-5166; author reply 5166-5167.
  • Nabekura T, Kamiyama S, Kitagawa S. Effects of dietary chemopreventive phytochemicals on P-glycoprotein function. Biochem Biophys Res Commun 2005;327:866-870.
  • Naik RS, Mujumdar AM, Ghaskadbi S. Protection of liver cells from ethanol cytotoxicity by curcumin in liver slice culture in vitro. J Ethnopharmacol 2004;95:31-37.
  • Nanji AA, Jokelainen K, Tipoe GL et al. Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B–dependent genes. Am J Physiol Gastrointest Liver Physiol 2003;284:G321-327.
  • Natarajan C, Bright JJ. Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase–STAT pathway in T lymphocytes. J Immunol 2002;168:6506-6513.
  • Navis I, Sriganth P, Premalatha B. Dietary curcumin with cisplatin administration modulates tumour marker indices in experimental fibrosarcoma. Pharmacol Res 1999;39:175-179.
  • Nishiyama T, Mae T, Kishida H et al. Curcuminoids and sesquiterpenoids in turmeric ( Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. J Agric Food Chem 2005;53:959-963.
  • Notarbartolo M, Poma P, Perri D et al. Antitumor effects of curcumin, alone or in combination with cisplatin or doxorubicin, on human hepatic cancer cells: analysis of their possible relationship to changes in NF-κB activation levels and in IAP gene expression. Cancer Lett 2005;224:53-65.
  • Oetari S, Sudibyo M, Commandeur JN et al. Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver. Biochem Pharmacol 1996;51:39-45.
  • Osawa T, Kato Y. Protective role of antioxidative food factors in oxidative stress caused by hyperglycemia. Ann N Y Acad Sci 2005;1043:440-451
  • Prusty BK, Das BC. Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcumin. Int J Cancer 2005;113:951-960.
  • Punithavathi D, Venkatesan N, Babu M. Curcumin inhibition of bleomycin-induced pulmonary fibrosis in rats. Br J Pharmacol 2000;131:169-172.
  • Rafatullah S, Tariq M, Al-Yahya MA et al. Evaluation of turmeric (Curcuma longa) for gastric and duodenal antiulcer activity in rats. J Ethnopharmacol 1990;29:25-34.
  • Rajakrishnan V, Jayadeep A, Arun OS et al. Changes in the prostaglandin levels in alcohol toxicity: effect of curcumin and N-acetylcysteine. J Nutr Biochem 2000;11:509-514.
  • Rajakrishnan V, Shiney SJ, Sudhakaran PR, Menon VP. Effect of curcumin on ethanol-induced stress on mononuclear cells. Phytother Res 2002;16:171-173.
  • Rajakrishnan V, Viswanathan P, Rajasekharan KN, Menon VP. Neuroprotective role of curcumin from Curcuma longa on ethanol-induced brain damage. Phytother Res 1999;13:571-574.
  • Ranjan D, Chen C, Johnston TD et al. Curcumin inhibits mitogen-stimulated lymphocyte proliferation, NF kB activation, and IL-2 signaling. J Surg Res 2004;121:171-177.
  • Ranjan D, Johnston TD, Wu G et al. Curcumin blocks cyclosporine A–resistant CD28 costimulatory pathway of human T-cell proliferation. J Surg Res 1998;77:174-178.
  • Rashmi R, Kumar S, Karunagaran D. Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their down-regulation potentiates it. Carcinogenesis 2004;25:1867–77
  • Raucy JL. Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products. Drug Metab Dispos 2003;31:533-539.
  • Rinaldi AL, Morse MA, Fields HW et al. Curcumin activates the aryl hydrocarbon receptor yet significantly inhibits (-)-benzo(a)pyrene-7R-trans-7,8-dihydrodiol bioactivation in oral squamous cell carcinoma cells and oral mucosa. Cancer Res 2002;62:5451-5456.
  • Rukkumani R, Aruna K, Varma PS et al. Comparative effects of curcumin and an analog of curcumin on alcohol and PUFA induced oxidative stress. J Pharm Pharm Sci 2004;7:274-283.
  • Rukkumani R, Aruna K, Varma PS, Menon VP. Curcumin influences hepatic expression patterns of matrix metalloproteinases in liver toxicity. Ital J Biochem 2004;53:61-66.
  • Salvioli S, Sikora E, Cooper EL e Franceschi C Curcumin in Cell Death Processes: A Challenge for CAM of Age-Related Pathologies eCAM 2007;doi:10.1093/ecam/nem043
  • Santibanez JF, Quintanilla M, Martinez J. Genistein and curcumin block TGF-beta 1-induced u-PA expression and migratory and invasive phenotype in mouse epidermal keratinocytes. Nutr Cancer 2000;37:49-54.
  • Shah BH, Nawaz Z, Pertani SA et al. Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor– and arachidonic acid–mediated platelet aggregation through inhibition of thromboxane formation and Ca 2+ signaling. Biochem Pharmacol 1999;58:1167-1172.
  • Sharma RA, McLelland HR, Hill KA et al. Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin Cancer Res 2001;7:1894-1900.
  • Shoba G, Joy D, Joseph T et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 1998;64:353-356.
  • Somasundaram S, Edmund NA, Moore DT et al. Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res 2002;62:3868-3875.
  • Srivastava KC, Bordia A, Verma SK. Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets. Prostaglandins Leukot Essent Fatty Acids 1995;52:223-227.
  • Srivastava R, Dikshit M, Srimal RC, Dhawan BN. Anti-thrombotic effect of curcumin. Thromb Res 1985;40:413-417.
  • Srivastava R, Puri V, Srimal RC, Dhawan BN. Effect of curcumin on platelet aggregation and vascular prostacyclin synthesis. Arzneimittelforschung 1986;36:715-717.
  • Suryanarayana P, Saraswat M, Mrudula T et al. Curcumin and turmeric delay streptozotocin-induced diabetic cataract in rats. Invest Ophthalmol Vis Sci 2005;46:2092-2099.
  • Swarnakar S, Ganguly K, Kundu P et al. Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. J Biol Chem 2005;280:9409-9415.
  • Thapliyal R, Deshpande SS, Maru GB. Effects of turmeric on the activities of benzo(a)pyrene-induced cytochrome P-450 isozymes. J Environ Pathol Toxicol Oncol 2001;20:59-63.
  • Thapliyal R, Maru GB. Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo. Food Chem Toxicol 2001;39:541-547.
  • Van’t Land B, Blijlevens NM, Marteijn J et al. Role of curcumin and the inhibition of NF-κB in the onset of chemotherapy-induced mucosal barrier injury. Leukemia 2004;18:276-284.
  • Venkatesan N, Chandrakasan G. Modulation of cyclophosphamide-induced early lung injury by curcumin, an anti-inflammatory antioxidant. Mol Cell Biochem 1995;142:79-87.
  • Venkatesan N, Punithavathi D, Arumugam V. Curcumin prevents Adriamycin nephrotoxicity in rats. Br J Pharmacol 2000;129:231-234.
  • Venkatesan N, Punithavathi V, Chandrakasan G. Curcumin protects bleomycin-induced lung injury in rats. Life Sci 1997;61:PL51-58.
  • Venkatesan N. Curcumin attenuation of acute Adriamycin myocardial toxicity in rats. Br J Pharmacol 1998;124:425-427.
  • Verma SP, Goldin BR. Copper modulates activities of genistein, nitric oxide, and curcumin in breast tumor cells. Biochem Biophys Res Commun 2003;310:104-108.
  • Verma SP, Salamone E, Goldin B. Curcumin and genistein, plant natural products, show synergistic inhibitory effects on the growth of human breast cancer MCF-7 cells induced by estrogenic pesticides. Biochem Biophys Res Commun 1997;233:692-696.
  • WHO. Rhizoma curcumae longae. WHO Monographs on Selected Medicinal Plants. 1 vol. Geneva: World Health Organization; 1999:115-124.
  • Yance, D. R., Jr. and S. M. Sagar (2006). “Targeting angiogenesis with integrative cancer therapies.” Integr Cancer Ther 5(1): 9-29 Howitz, K.T., Bitterman, K.J., Cohen, H.Y., Lamming, D.W., Lavu, S., Wood, J.G., et al. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425: 191–196. Oberdoerffer et al 2008) "SIRT1 redistribution on chromatin promotes genome stability but alters gene expression during aging"; Cell 135, 6
  • Yeh C-H, Chen T-P, Wu Y-C et al. Inhibition of NFκB activation with curcumin attenuates plasma inflammatory cytokines surge and cardiomyocytic apoptosis following cardiac ischemia/reperfusion. J Surg Res 2005;125:109-116.
  • Yoysungnoen P, Wirachwong P, Bhattarakosol P et al. Effects of curcumin on tumor angiogenesis and biomarkers, COX-2 and VEGF, in hepatocellular carcinoma cell-implanted nude mice. Clin Hemorheol Microcirc 2006;34:109-115.
  • Zhou S, Lim LY, Chowbay B. Herbal Modulation of P-glycoprotein. Drug Metab Rev 2004;36:57-104
Tue, 20 Jan 2009 21:37:40 +0100


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